4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Names and Identifiers

Name	5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one
Synonyms	GINKGETIN ginkgetin GINKGETIN(RG)(PLEASE CALL) 4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one 5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)- 4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-
CAS	481-46-9
InChI	InChI=1/C32H22O10/c1-39-18-10-20(34)30-23(37)13-27(41-28(30)11-18)16-5-8-25(40-2)19(9-16)29-21(35)12-22(36)31-24(38)14-26(42-32(29)31)15-3-6-17(33)7-4-15/h3-14,33-36H,1-2H3

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Physico-chemical Properties

Molecular Formula	C32H22O10
Molar Mass	566.51
Density	1.506±0.06 g/cm3(Predicted)
Melting Point	297 °C(Solv: acetone (67-64-1))
Boling Point	863.7±65.0 °C(Predicted)
Flash Point	287.1°C
Solubility	DMSO : ≥ 83.3 mg/mL (147.04 mM)
Vapor Presure	2.28E-31mmHg at 25°C
Appearance	White crystalline powder
pKa	6.18±0.40(Predicted)
Storage Condition	2-8℃
Refractive Index	1.714
MDL	MFCD09970948
Physical and Chemical Properties	Soluble in methanol, ethanol, DMSO and other organic solvents, from Ginkgo biloba.

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference

Reference

1. Zhang, Lei, Jiangang Liu, and Tao Geng. "Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor‐kB signaling pathway in ischemic‐reperfusion injury." Journal of cellular biochemistry 120.5 (2019): 8078-8085.https://doi
2. Xu, Bing, et al. "Ginkgetin aglycone attenuates neuroinflammation and neuronal injury in the rats with ischemic stroke by modulating STAT3/JAK2/SIRT1." Folia Neuropathol 57.1 (2019): 16-23.https://doi.org/10.5114/fn.2019.83827
3. [IF=5.396] Zhu Tao et al."Evaluation of the anti-inflammatory properties of the active constituents in Ginkgo biloba for the treatment of pulmonary diseases."Food Funct. 2019 Apr;10(4):2209-2220
4. [IF=4.411] Li Yang et al."Seasonal Dynamics of Metabolites in Needles of Taxus wallichiana var. mairei."Molecules. 2016 Oct;21(10):1403
5. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference Information

biological activity	Ginkgetin is a diflavone isolated from ginkgo biloba. Ginkgetin has anti-tumor, anti-inflammatory, neuroprotective and antifungal effects. Ginkgetin is also a potent inhibitor of Wnt signaling with an IC50 value of 5.92 μM.
Cell Line:	Daoy and D283 cell lines Osteosarcoma cells Daoy cells Daoy and D283 cell lines
Concentration:	2.5, 5, 10, 20 μM 20, 30, 40 μM 2.5, 5, 10, 20 μM 10, 20 μM
Incubation Time:	48 hours 24 hours 24 hours 3, 6, 12, 24 hours
Result:	Inhibited the cell growth, with IC 50 s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively. Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner. Increased G 2 /M phase, compared with that of control, indicating a G 2 /M cell phase arrest. Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells. Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner. Reduced the neurological deﬁcit score. Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα. Decreased the expressions of ICAM-1, COX-2, and iNOS. Downregulated downstream inﬂammatory factor PGE2 and TNF-α expression. Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
Animal Model:	Male Sprague-Dawley rats (200-220 g)
Dosage:	25, 50, 100 mg/kg
Administration:	I.p. 2 hours after the onset of ischemia
use	ginkgo biloba has the effects of regulating blood lipid, lowering cholesterol and treating angina pectoris. used for content determination/identification/pharmacological experiment, etc.

Last Update：2024-04-09 21:11:58

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-

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Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: ginkgetin Visit Supplier Webpage Request for quotation
CAS: 481-46-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one

CAS: 481-46-9

Molecular Formula: C32H22O10

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Names and Identifiers

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Physico-chemical Properties

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference Information

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4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- Request for Quotation

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one

CAS: 481-46-9

Molecular Formula: C32H22O10

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Names and Identifiers

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Physico-chemical Properties

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference

4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- - Reference Information

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4H-1-benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-